Differentially Expressed Tear Proteins in Sjogren's Syndrome Keratoconjunctivitis Sicca.

ABSTRACT:

Purpose

The purpose of this study was to determine if there are significant differences in the concentrations of tear proteins in Sjögren's syndrome keratoconjunctivitis sicca (SS KCS) compared to healthy controls.

Methods

Tear samples were collected with unmarked Schirmer strips from 15 patients with SS KCS and 21 healthy controls. Tear protein was eluted and the concentration measured. Inflammatory mediators were assayed with a Raybiotech L-507 glass slide array and normalized by strip wetting length. All patients underwent an ocular surface exam to evaluate tear break-up time (TBUT), corneal fluorescein (CF) staining, and conjunctival (CJ) staining. The symptom assessment questionnaire in dry eye (SANDE) scores were collected for all patients.

Results

Two hundred f

SUBMITTER: Yoon SP 

PROVIDER: S-EPMC10275389 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature