Efficacy and safety of ketamine for neonatal refractory status epilepticus: case report and systematic review.

ABSTRACT:

Background

Evidence-based data on treatment of neonatal status epilepticus (SE) are scarce. We aimed to collect data on the efficacy and safety of ketamine for the treatment of neonatal SE and to assess its possible role in the treatment of neonatal SE.

Methods

We described a novel case and conducted a systematic literature review on neonatal SE treated with ketamine. The search was carried out in Pubmed, Cochrane, Clinical Trial Gov, Scopus and Web of Science.

Results

Seven published cases of neonatal SE treated with ketamine were identified and analyzed together with our novel case. Seizures typically presented during the first 24 h of life (6/8). Seizures were resistant to a mean of five antiseizure medications. Ketamine, a NMDA receptor antagonist, appeared to be

SUBMITTER: Pin JN 

PROVIDER: S-EPMC10275409 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature