Mathematical properties of optimal fluxes in cellular reaction networks at balanced growth.

ABSTRACT: The physiology of biological cells evolved under physical and chemical constraints, such as mass conservation across the network of biochemical reactions, nonlinear reaction kinetics, and limits on cell density. For unicellular organisms, the fitness that governs this evolution is mainly determined by the balanced cellular growth rate. We previously introduced growth balance analysis (GBA) as a general framework to model and analyze such nonlinear systems, revealing important analytical properties of optimal balanced growth states. It has been shown that at optimality, only a minimal subset of reactions can have nonzero flux. However, no general principles have been established to determine if a specific reaction is active at optimality. Here, we extend the GBA framework to study the optim

SUBMITTER: Dourado H 

PROVIDER: S-EPMC10275479 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature