Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs.

ABSTRACT: How changes in the different steps of protein synthesis-transcription, translation and degradation-contribute to differences of protein abundance among genes is not fully understood. There is however accumulating evidence that transcriptional divergence might have a prominent role. Here, we show that yeast paralogous genes are more divergent in transcription than in translation. We explore two causal mechanisms for this predominance of transcriptional divergence: an evolutionary trade-off between the precision and economy of gene expression and a larger mutational target size for transcription. Performing simulations within a minimal model of post-duplication evolution, we find that both mechanisms are consistent with the observed divergence patterns. We also investigate how additional pro

SUBMITTER: Aube S 

PROVIDER: S-EPMC10275480 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature