Type 2 diabetes, obesity, and risk of amyotrophic lateral sclerosis: A population-based cohort study.

ABSTRACT:

Background

Type 2 diabetes and obesity may be inversely associated with amyotrophic lateral sclerosis (ALS), but the evidence is controversial.

Methods

Using Danish, nationwide registries (1980-2016), we identified patients with a diagnosis of type 2 diabetes (N = 295,653) and patients with a diagnosis of obesity (N = 312,108). Patients were matched (1:3) to persons from the general population on birth year and sex. We computed incidence rates and Cox regression derived hazard ratios (HRs) of a diagnosis of ALS. In multivariable analyses, HRs were controlled for sex, birth year, calendar year, and comorbidities.

Results

We observed 168 incident cases of ALS (0.7 [95% confidence interval (CI): 0.6-0.8] per 10,000 person-years) among patients with type 2 diabetes and 85

SUBMITTER: Skajaa N 

PROVIDER: S-EPMC10275529 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature