Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder.

ABSTRACT:

Introduction

The barrier function of the gut is important for many organs and systems, including the brain. If gut permeability increases, bacterial fragments may enter the circulation, giving rise to increased systemic inflammation. Increases in bacterial translocation are reflected in higher values of blood markers, including lipopolysaccharide binding protein (LBP) and soluble cluster of differentiation 14 (sCD14). Some pioneer studies showed a negative association between bacterial translocation markers and brain volumes, but this association remains scarcely investigated. We investigate the effect of bacterial translocation on brain volumes and cognition in both healthy controls and patients with a schizophrenia spectrum disorder (SSD).

Materials and methods

Healthy con

SUBMITTER: Scheurink TAW 

PROVIDER: S-EPMC10275537 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature