Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder.

ABSTRACT:

Objectives

Bipolar disorder (BD) is a severe, chronic, affective disorder characterized by recurrent switching between mood states, psychomotor and cognitive symptoms, which can linger in euthymic states as residual symptoms. Hippocampal alterations may play a key role in the neural processing of BD symptoms. However, its dynamic functional connectivity (dFC) remains unclear. Therefore, the present study explores hippocampal dFC in relation to BD symptoms.

Methods

We assessed hippocampus-based dFC coactivation patterns (CAPs) on resting-state fMRI data of 25 euthymic BD patients and 25 age- and sex-matched healthy controls (HC).

Results

Bilateral hippocampal dFC with somatomotor networks (SMN) was reduced in BD, compared to HC, while at the same time dFC between the l

SUBMITTER: Saccaro LF 

PROVIDER: S-EPMC10275545 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature