Impaired Myocardial Flow Reserve on ⁸²Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.

ABSTRACT:

Objective

To investigate the association between Raynaud phenomenon (RP) and coronary microvascular dysfunction, we measured myocardial flow reserve (MFR) using positron emission tomography/computed tomography (PET/CT) in patients with primary and secondary RP and controls.

Methods

Patients with RP, patient controls, and healthy participants who underwent dynamic rest-stress 82-rubidium PET/CT were studied. Differences in heart rate-blood pressure product-corrected MFR and clinical predictors of reduced MFR (< 2.0) were determined.

Results

Forty-nine patients with RP (80% female; aged 65 ± 11 yrs; 11 with primary RP, 18 with systemic sclerosis [SSc], and 20 with other autoimmune rheumatic diseases [AIRDs] including 6 with systemic lupus erythematosus, 6 with rheumatoi

SUBMITTER: Feher A 

PROVIDER: S-EPMC10275580 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature