Modes of Selection in Tumors as Reflected by Two Mathematical Models and Site Frequency Spectra.

ABSTRACT: The tug-of-war model was developed in a series of papers of McFarland and co-authors to account for existence of mutually counteracting rare advantageous driver mutations and more frequent slightly deleterious passenger mutations in cancer. In its original version, it was a state-dependent branching process. Because of its formulation, the tug-of-war model is of importance for tackling the problem as to whether evolution of cancerous tumors is "Darwinian" or "non-Darwinian." We define two Time-Continuous Markov Chain versions of the model, including identical mutation processes but adopting different drift and selection components. In Model A, drift and selection process preserves expected fitness whereas in Model B it leads to non-decreasing expected fitness. We investigate these properti

SUBMITTER: Kurpas MK 

PROVIDER: S-EPMC10275603 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature