Inflammatory markers and tract-based structural connectomics in older adults with a preliminary exploration of associations by race.

ABSTRACT: Peripheral inflammation has been implicated in cognitive dysfunction and dementia. While studies outline the relationship between elevated inflammation and individual gray or white matter alterations, less work has examined inflammation as related to connectivity between gray and white matter or variability in these associations by race. We examined the relationship between peripheral inflammation and tract-based structural connectomics in 74 non-demented participants (age = 69.19 ± 6.80 years; 53% female; 45% Black) who underwent fasting venipuncture and MRI. Serum was assayed for C-reactive protein, interleukin-6, and interleukin-1β. Graph theory analysis integrated T1-derived gray matter volumes and DTI-derived white matter tractography into connectivity matrices analyzed for local meas

SUBMITTER: Boots EA 

PROVIDER: S-EPMC10275616 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature