Real-world effectiveness of nirmatrelvir/ritonavir against COVID-19 hospitalisations and severe COVID-19 in community-dwelling elderly Singaporeans during Omicron BA.2, BA.4/5 and XBB transmission.

ABSTRACT:

Objectives

Real-world data on continued effectiveness of nirmatrelvir/ritonavir against hospitalisation and severe COVID-19 in the context of widespread booster mRNA vaccine uptake and more immune-evasive Omicron subvariants is lacking. We conducted a retrospective cohort study in adult Singaporeans aged ≥60 years presenting to primary care with SARS-CoV-2 infection, during waves of Omicron BA.2/4/5/XBB transmission.

Methods

Binary logistic regression was used to estimate the effect of treatment (receiving nirmatrelvir/ritonavir) on outcomes (hospitalisation, severe COVID-19). Additional sensitivity analyses, including inverse-probability-of-treatment-weighting-adujsted analysis (IPTW) and adjustment using overlap weights, were performed to account for observed differences i

SUBMITTER: Wee LE 

PROVIDER: S-EPMC10275656 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature