Unique features of the TCR repertoire of reactivated memory T cells in the experimental mouse tumor model.

ABSTRACT: T cell engineering with T cell receptors (TCR) specific to tumor antigens has become a breakthrough towards personalized cancer adoptive cell immunotherapy. However, the search for therapeutic TCRs is often challenging, and effective strategies are strongly required for the identification and enrichment of tumor-specific T cells that express TCRs with superior functional characteristics. Using an experimental mouse tumor model, we studied sequential changes in TCR repertoire features of T cells involved in the primary and secondary immune responses to allogeneic tumor antigens. In-depth bioinformatics analysis of TCR repertoires showed differences in reactivated memory T cells compared to primarily activated effectors. After cognate antigen re-encounter, memory cells were enriched with clo

SUBMITTER: Kalinina A 

PROVIDER: S-EPMC10275742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature