Ontology highlight
ABSTRACT:
SUBMITTER: Cordner R
PROVIDER: S-EPMC10275753 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Cordner Ryan R Jhun Michelle M Panwar Akanksha A Wang HongQiang H Gull Nicole N Murali Ramachandran R McAbee Joseph H JH Mardiros Armen A Sanchez-Takei Akane A Mazer Mia W MW Fan Xuemo X Jouanneau Emmanuel E Yu John S JS Black Keith L KL Wheeler Christopher J CJ
Oncogene 20230509 25
The promise of adaptive cancer immunotherapy in treating highly malignant tumors such as glioblastoma multiforme (GBM) can only be realized through expanding its benefits to more patients. Alleviating various modes of immune suppression has so far failed to achieve such expansion, but exploiting endogenous immune enhancers among mutated cancer genes could represent a more direct approach to immunotherapy improvement. We found that Isocitrate Dehydrogenase-1 (IDH1), which is commonly mutated in g ...[more]