Particulate cartilage and platelet-rich plasma treatment for knee chondral defects in sheep.

ABSTRACT:

Purpose

Articular cartilage is vulnerable to multiple types of damage and it has limited reparative and regenerative capacities due to its absence of vascularity. Although a large number of therapeutic strategies exist to treat chondral defects, they have some limitations, such as fibrocartilage formation. Therefore, the goal of the present study was to evaluate the chondrogenic regenerative properties of an autologous-made matrix of particulated cartilage and platelet-rich plasma (PACI + PRP) implantation for the treatment of full-thickness chondral defects in sheep.

Methods

A full-thickness 8 mm diameter cartilage defect was created in the weight-bearing area of the medial femoral condyle in both knees of 16 sheep. The right knees of all animals were treated with particula

SUBMITTER: Alcaide-Ruggiero L 

PROVIDER: S-EPMC10275813 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature