Average power and burst analysis revealed complementary information on drug-related changes of motor performance in Parkinson's disease.

ABSTRACT: In patients with Parkinson's disease (PD), suppression of beta and increase in gamma oscillations in the subthalamic nucleus (STN) have been associated with both levodopa treatment and motor functions. Recent results suggest that modulation of the temporal dynamics of theses oscillations (bursting activity) might contain more information about pathological states and behaviour than their average power. Here we directly compared the information provided by power and burst analyses about the drug-related changes in STN activities and their impact on motor performance within PD patients. STN local field potential (LFP) signals were recorded from externalized patients performing self-paced movements ON and OFF levodopa. When normalised across medication states, both power and burst analyses sh

SUBMITTER: Torrecillos F 

PROVIDER: S-EPMC10275865 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature