Ontology highlight
ABSTRACT:
SUBMITTER: Iemolo A
PROVIDER: S-EPMC10275870 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Iemolo Attilio A De Risi Maria M Giordano Nadia N Torromino Giulia G Somma Cristina C Cavezza Diletta D Colucci Martina M Mancini Maria M de Iure Antonio A Granata Rocco R Picconi Barbara B Calabresi Paolo P De Leonibus Elvira E
NPJ Parkinson's disease 20230616 1
Cognitive deficits, including working memory, and visuospatial deficits are common and debilitating in Parkinson's disease. α-synucleinopathy in the hippocampus and cortex is considered as the major risk factor. However, little is known about the progression and specific synaptic mechanisms underlying the memory deficits induced by α-synucleinopathy. Here, we tested the hypothesis that pathologic α-Synuclein (α-Syn), initiated in different brain regions, leads to distinct onset and progression o ...[more]