Association between systemic omega-3 polyunsaturated fatty acid levels, and corneal nerve structure and function.

ABSTRACT:

Background

Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have anti-inflammatory and neuroprotective properties. This study sought to determine the relationship between corneal parameters and systemic omega-3 fatty acid levels.

Methods

Forty-seven participants with no/mild peripheral neuropathy (26 with diabetes and 21 without) underwent comprehensive ocular surface and systemic PUFA assessments. Corneal anatomical parameters were assessed using in vivo confocal microscopy. Corneal sensitivity was measured using non-contact esthesiometry. Relationships between systemic PUFA levels and corneal parameters were evaluated with multiple linear regression, adjusted for age, sex, neuropathy symptom score, and presence of dia

SUBMITTER: Britten-Jones AC 

PROVIDER: S-EPMC10275886 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature