Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia.

ABSTRACT: The bone marrow (BM) is a complex microenvironment, coordinating the production of billions of blood cells every day. Despite its essential role and its relevance to hematopoietic diseases, this environment remains poorly characterized. Here we present a high-resolution characterization of the niche in health and acute myeloid leukemia (AML) by establishing a single-cell gene expression database of 339,381 BM cells. We found significant changes in cell type proportions and gene expression in AML, indicating that the entire niche is disrupted. We then predicted interactions between hematopoietic stem and progenitor cells (HSPCs) and other BM cell types, revealing a remarkable expansion of predicted interactions in AML that promote HSPC-cell adhesion, immunosuppression, and cytokine signalin

SUBMITTER: Ennis S 

PROVIDER: S-EPMC10275994 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature