Structural impact of arrested foveal development in children born extremely preterm without ROP at 6.5 years of age.

ABSTRACT:

Objectives

To characterize changes of foveal topography and microstructure of persisting foveal immaturity at 6.5 years of age in children born extremely preterm without retinopathy of prematurity (EPT-NoROP).

Methods

Images from previous optical coherence tomography examinations of 37 EPT-NoROP and 92 control eyes were selected from a regional cohort of the EXPRESS (Extremely Preterm Infants in Sweden) study. Thickness of ganglion cell + inner plexiform layer (GCL+), outer nuclear layer (ONL), retinal thickness (RT) at the foveal centre (FC), foveal depth (FD) and RT at the foveal rim were evaluated.

Results

Layer thickness of GCL+, ONL and RT was increased at FC in the EPT-NoROP group. More than two-thirds had thickness values above the control limit (control mean +

SUBMITTER: Venkataraman AP 

PROVIDER: S-EPMC10276016 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature