Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial.

ABSTRACT: Combined oral contraceptives (COC) are among the most commonly used contraceptive methods worldwide, and mood side effects are the major reason for discontinuation of treatment. We here investigate the directed connectivity patterns associated with the mood side effects of an androgenic COC in a double-blind randomized, placebo-controlled trial in women with a history of affective COC side effects (n = 34). We used spectral dynamic causal modeling on a triple network model consisting of the default mode network (DMN), salience network (SN) and executive control network (ECN). Within this framework, we assessed the treatment-related changes in directed connectivity associated with adverse mood side effects. Overall, during COC use, we found a pattern of enhanced connectivity within the DMN

SUBMITTER: Hidalgo-Lopez E 

PROVIDER: S-EPMC10276024 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature