Ontology highlight
ABSTRACT:
SUBMITTER: Wu W
PROVIDER: S-EPMC10276051 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Wu Wenjie W Xu Jialuo J Gao Dan D Xie Zhenliang Z Chen Wenjing W Li Wenjing W Yuan Qiang Q Duan Lina L Zhang Yuhan Y Yang Xiaoxiao X Chen Yingying Y Dong Ziming Z Liu Kangdong K Jiang Yanan Y
Cell death & disease 20230616 6
T-LAK-originated protein kinase (TOPK), a dual specificity serine/threonine kinase, is up-regulated and related to poor prognosis in many types of cancers. Y-box binding protein 1 (YB1) is a DNA/RNA binding protein and serves important roles in multiple cellular processes. Here, we reported that TOPK and YB1 were both highly expressed in esophageal cancer (EC) and correlated with poor prognosis. TOPK knockout effectively suppressed EC cell proliferation and these effects were reversible by rescu ...[more]