Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study.

ABSTRACT: Despite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been associated with lower RA risk. We aimed to explore the repurposing potential of antidiabetic drugs in RA prevention by assessing associations between genetic variation in antidiabetic drug target genes and RA using Mendelian randomization (MR). A two-sample MR design was used to estimate the association between the antidiabetic drug and RA risk using summary statistics from genome-wide association studies (GWAS). We selected independent genetic variants from the gene(s) that encode the target protein(s) of the investigated antidiabetic drug as instruments. We extracted the associations of instruments with bl

SUBMITTER: Qin C 

PROVIDER: S-EPMC10276071 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature