Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study.

ABSTRACT: Musculoskeletal conditions, including fractures, can have severe and long-lasting consequences. Higher body mass index in adulthood is widely acknowledged to be protective for most fracture sites. However, sources of bias induced by confounding factors may have distorted previous findings. Employing a lifecourse Mendelian randomisation (MR) approach by using genetic instruments to separate effects at different life stages, this investigation aims to explore how prepubertal and adult body size independently influence fracture risk in later life.Using data from a large prospective cohort, univariable and multivariable MR were conducted to simultaneously estimate the effects of age-specific genetic proxies for body size (n = 453,169) on fracture risk (n = 416,795). A two-step MR framework was

SUBMITTER: Power GM 

PROVIDER: S-EPMC10276076 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature