Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization.

ABSTRACT: Lifecourse Mendelian randomization is a causal inference technique which harnesses genetic variants with time-varying effects to develop insight into the influence of age-dependent lifestyle factors on disease risk. Here, we apply this approach to evaluate whether childhood body size has a direct consequence on 8 major disease endpoints by analysing parental history data from the UK Biobank study.Our findings suggest that, whilst childhood body size increases later risk of outcomes such as heart disease (odds ratio (OR) = 1.15, 95% CI = 1.07 to 1.23, P = 7.8 × 10^- 5) and diabetes (OR = 1.43, 95% CI = 1.31 to 1.56, P = 9.4 × 10^- 15) based on parental history data, these findings are likely attributed to a sustained influence of being overweight for many years over the

SUBMITTER: Richardson TG 

PROVIDER: S-EPMC10276123 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature