Effect of Radiotherapy Dose on Outcome in Nonmetastatic Ewing Sarcoma.

ABSTRACT:

Purpose

Radiation therapy (RT) is an integral part of Ewing sarcoma (EwS) therapy. The Ewing 2008 protocol recommended RT doses ranging from 45 to 54 Gy. However, some patients received other doses of RT. We analyzed the effect of different RT doses on event-free survival (EFS) and overall survival (OS) in patients with EwS.

Methods and materials

The Ewing 2008 database included 528 RT-admitted patients with nonmetastatic EwS. Recommended multimodal therapy consisted of multiagent chemotherapy and local treatment consisting of surgery (S&RT group) and/or RT (RT group). EFS and OS were analyzed with uni- and multivariable Cox regression models including known prognostic factors such as age, sex, tumor volume, surgical margins, and histologic response.

Results

S&RT was

SUBMITTER: Kersting J 

PROVIDER: S-EPMC10276219 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature