High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML.

ABSTRACT:

Background

As a core member of the FA complex, in the Fanconi anemia pathway, FAAP24 plays an important role in DNA damage repair. However, the association between FAAP24 and patient prognosis in AML and immune infiltration remains unclear. The purpose of this study was to explore its expression characteristics, immune infiltration pattern, prognostic value and biological function using TCGA-AML and to verify it in the Beat AML cohort.

Methods

In this study, we examined the expression and prognostic value of FAAP24 across cancers using data from TCGA, TARGET, GTEx, and GEPIA2. To further investigate the prognosis in AML, development and validation of a nomogram containing FAAP24 were performed. GO/KEGG, ssGSEA, GSVA and xCell were utilized to explore the functional enrichmen

SUBMITTER: Bao X 

PROVIDER: S-EPMC10276373 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature