Endoplasmic reticulum stress-related gene model predicts prognosis and guides therapies in lung adenocarcinoma.

ABSTRACT:

Background

The prognosis and survival of lung adenocarcinoma (LUAD) patients are still not promising despite recent breakthroughs in treatment. Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear.

Methods

LASSO and Cox regression were applied based on sequencing information to construct the model, which was validated to be robust. The risk scores of the patients were calculated using the formula provided by the model, and the patients were divided into high and low-risk groups according to th

SUBMITTER: Song Y 

PROVIDER: S-EPMC10276379 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature