A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury.

ABSTRACT:

Background

Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia-the most common risk factor in humans-and analyze the additional effect of ventilator-induced lung injury (VILI).

Methods

Bronchoscopy-guided instillation of a multidrug-resistant Pseudomonas aeruginosa strain was performed in ten healthy pigs. In six animals (pneumonia-with-VILI group), pulmonary damage was further increased by VILI applied 3 h before instillation and until ARDS was diagnosed by PaO₂/FiO₂ < 150 mmHg. Four animals (pneumonia-without-VILI group) were protectively ventilated 3 h before inoculum and thereafter. Gas exchange, res

SUBMITTER: Barbeta E 

PROVIDER: S-EPMC10276390 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature