Microenvironment modulation by key regulators of RNA N6-methyladenosine modification in respiratory allergic diseases.

ABSTRACT:

Background

RNA N6-methyladenosine (m6A) regulators are considered post-transcriptional regulators that affect several biological functions, and their role in immunity, in particular, is emerging. However, the role of m6A regulators in respiratory allergic diseases remains unclear. Therefore, we aimed to investigate the role of key m6A regulators in mediating respiratory allergic diseases and immune microenvironment infiltration characteristics.

Methods

We downloaded gene expression profiles of respiratory allergies from the Gene Expression Omnibus (GEO) database and we performed hierarchical clustering, difference analysis, and construction of predictive models to identify hub m6A regulators that affect respiratory allergies. Next, we investigate the underlying biological me

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10276419 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature