Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents.

ABSTRACT:

Background

The carbazole skeleton is an important structural motif occurring naturally or synthesized chemically and has antihistaminic, antioxidant, antitumor, antimicrobial, and anti-inflammatory activities.

Objectives

This study aimed to design and synthesize a novel series of carbazole derivatives and evaluate their antiproliferative and antioxidant activities.

Methods

The synthesized compounds were characterized utilizing HRMS, ¹H-, and ¹³C_APT-NMR, and assessed for their anticancer, antifibrotic, and antioxidant effects utilizing reference biomedical procedures. In addition, the AutoDock Vina application was used to perform in-silico docking computations.

Results

A series of carbazole derivatives were synthesized and charac

SUBMITTER: Capan I 

PROVIDER: S-EPMC10276425 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature