Identification of a novel risk factor for chronic wasting disease (CWD) in elk: S100G single nucleotide polymorphism (SNP) of the prion protein gene (PRNP).

ABSTRACT: Prion diseases are fatal and malignant infectious encephalopathies induced by the pathogenic form of prion protein (PrP^Sc) originating from benign prion protein (PrP^C). A previous study reported that the M132L single nucleotide polymorphism (SNP) of the prion protein gene (PRNP) is associated with susceptibility to chronic wasting disease (CWD) in elk. However, a recent meta-analysis integrated previous studies that did not find an association between the M132L SNP and susceptibility to CWD. Thus, there is controversy about the effect of M132L SNP on susceptibility to CWD. In the present study, we investigated novel risk factors for CWD in elk. We investigated genetic polymorphisms of the PRNP gene by amplicon sequencing and compared genotype, allele, and haplotype fr

SUBMITTER: Lee YR 

PROVIDER: S-EPMC10276480 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature