A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study.

ABSTRACT:

Background

The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU.

Methods

This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group.

Results

Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort

SUBMITTER: de Gonzalo-Calvo D 

PROVIDER: S-EPMC10276486 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature