A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer.

ABSTRACT:

Background

Early detection is critical for improving the survival of breast cancer (BC) patients. Exhaled breath testing as a non-invasive technique might help to improve BC detection. However, the breath test accuracy for BC diagnosis is unclear.

Methods

This multi-center cohort study consecutively recruited 5047 women from four areas of China who underwent BC screening. Breath samples were collected through standardized breath collection procedures. Volatile organic compound (VOC) markers were identified from a high-throughput breathomics analysis by the high-pressure photon ionization-time-of-flight mass spectrometry (HPPI-TOFMS). Diagnostic models were constructed using the random forest algorithm in the discovery cohort and tested in three external validation cohorts.

SUBMITTER: Liu J 

PROVIDER: S-EPMC10276488 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature