Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressants in pregnancy. Animal and some clinical studies have suggested potential increases in depression and anxiety following prenatal SSRI exposure, but the extent to which these are driven by the medication remains unclear. We used Danish population data to test associations between maternal SSRI use during pregnancy and children outcomes up to age 22.

Methods

We prospectively followed 1,094,202 single-birth Danish children born 1997-2015. The primary exposure was ≥ 1 SSRI prescription filled during pregnancy; the primary outcome, first diagnosis of a depressive, anxiety, or adjustment disorder, or redeemed prescription for an antidepressant medication. We used propensity

SUBMITTER: Bliddal M 

PROVIDER: S-EPMC10276495 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature