Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

ABSTRACT: Abstract

Background

Infiltration of glioblastoma (GBM) throughout the brain leads to its inevitable recurrence following standard-of-care treatments, such as surgical resection, chemo-, and radiotherapy. A deeper understanding of the mechanisms invoked by GBM to infiltrate the brain is needed to develop approaches to contain the disease and reduce recurrence. The aim of this study was to discover mechanisms through which extracellular vesicles (EVs) released by GBM influence the brain microenvironment to facilitate infiltration, and to determine how altered extracellular matrix (ECM) deposition by glial cells might contribute to this.

Methods

CRISPR was used to delete genes, previously established to drive carcinoma invasiveness and EV production, from patient-derived pri

SUBMITTER:  

PROVIDER: S-EPMC10276538 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature