Safety and efficacy of hydroxychloroquine as prophylactic against COVID-19 in healthcare workers: a meta-analysis of randomised clinical trials.

ABSTRACT:

Objective

We studied the safety and efficacy of hydroxychloroquine (HCQ) as pre-exposure prophylaxis for COVID-19 in healthcare workers (HCWs), using a meta-analysis of randomised controlled trials (RCTs).

Data sources

PubMed and EMBASE databases were searched to identify randomised trials studying HCQ.

Study selection

Ten RCTs were identified (n=5079 participants).

Data extraction and synthesis

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used in this systematic review and meta-analysis between HCQ and placebo using a Bayesian random-effects model. A pre-hoc statistical analysis plan was written.

Main outcomes

The primary efficacy outcome was PCR-confirmed SARS-CoV-2 infection and the primary safety outcome was

SUBMITTER: Hong H 

PROVIDER: S-EPMC10276967 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature