Combination immunochemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the efficacy and safety of combination immunochemotherapy regimens for the treatment of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC).

Design

Meta-analysis and systematic review.

Data sources

PubMed, Embase, Web of Science and Cochrane library and the Clinicaltrials.gov clinical trials registry were searched up to 14 March 2022.

Eligibility criteria for selecting studies

We included randomised controlled trials that compared combination immunochemotherapy with conventional chemotherapy for R/M HNSCC. Primary outcomes of interest were overall survival (OS), progression-free survival (PFS), objective response rate (ORR) and adverse effects (AEs).

Data extraction and synthesis

Two reviewers independently ext

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10277053 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature