Observed intervention effects for mortality in randomised clinical trials: a methodological study protocol.

ABSTRACT:

Introduction

It is essential to choose a realistic anticipated intervention effect when calculating a sample size for a randomised clinical trial. Unfortunately, anticipated intervention effects are often inflated, when compared with the 'true' intervention effects. This is documented for mortality in critical care trials. A similar pattern might exist across different medical specialties. This study aims to estimate the range of observed intervention effects for all-cause mortality in trials included in Cochrane Reviews, within each Cochrane Review Group.

Methods and analysis

We will include randomised clinical trials assessing all-cause mortality as an outcome. Trials will be identified from Cochrane Reviews published in the Cochrane Database of Systematic Reviews. Cochran

SUBMITTER: Hansen ML 

PROVIDER: S-EPMC10277072 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature