Efficacy and safety of botulinum toxin for treating motor dysfunction in patients with Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the efficacy and safety of botulinum toxin (BTX) for motor dysfunction in Parkinson's disease (PD).

Design

Systematic review and meta-analysis.

Data sources

Searches of PubMed, EMBASE and the Cochrane Library, from database inception to 20 October 2022.

Eligibility criteria

Studies reported in English with adult PD patients treated with BTX.

Data extraction and synthesis

Primary outcomes were United Parkinson's Disease Rate Scale Section (UPDRS) III (or its items) and Visual Analogue Scale (VAS). Secondary outcomes were UPDRS-II (or its items), Freezing of Gait Questionnaire (FOG-Q), Timed Up and Go test (TUG) and treatment-related adverse events (TRAEs). Mean difference (MD) or standardised MD (SMD) before and after treatment with

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10277107 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature