Clinical manifestations and approach to the management of patients with common variable immunodeficiency and liver disease.

ABSTRACT:

Purpose

The clinical spectrum of common variable immunodeficiency (CVID) includes predisposition to infections, autoimmune/inflammatory complications and malignancy. Liver disease is developed by a proportion of patients with CVID, but limited evidence is available about its prevalence, pathogenesis and prognostic outcome. This lack of evidence leads to the absence of guidelines in clinical practice. In this study, we aimed at defining the characteristics, course and management of this CVID complication in Spain.

Methods

Spanish reference centers were invited to complete a cross-sectional survey. Thirty-eight patients with CVID-related liver disease from different hospitals were evaluated by a retrospective clinical course review.

Results

In this cohort, abnormal live

SUBMITTER: Daza-Cajigal V 

PROVIDER: S-EPMC10277479 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature