Two tripartite classification systems of CD86⁺ and CD206⁺ macrophages are significantly associated with tumor recurrence in stage II-III colorectal cancer.

ABSTRACT:

Introduction

The prognostic value of tumor-associated macrophages remains unclear in colorectal cancer (CRC). Two tripartite classification systems, namely, ratio and quantity subgroups, were investigated as the prognostic stratification tools for stage II-III CRC.

Methods

We assessed the infiltration intensity of CD86⁺ and CD206⁺ macrophages in 449 cases with stage II-III disease by immunohistochemical staining. Ratio subgroups were defined by the lower- and upper-quartile points of CD206⁺/(CD86⁺+CD206⁺) macrophage ratio, including the low-, moderate-, and high-ratio subgroups. Quantity subgroups were defined by the median points of CD86⁺ and CD206⁺ macrophages and included the low-, moderate-, and

SUBMITTER: Xu G 

PROVIDER: S-EPMC10277500 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature