CD22 CAR T-cell associated hematologic toxicities, endothelial activation and relationship to neurotoxicity.

ABSTRACT:

Background

Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate with cytokine release syndrome (CRS) and neurotoxicity severity, but little is known about the extended toxicity profiles of CAR T-cells targeting alternative antigens. This report characterizes hematologic toxicities seen following CD22 CAR T-cells and their relationship to CRS and neurotoxicity.

Methods

We retrospectively characterized hematologic toxicities associated with CRS seen on a phase 1 study of anti-CD22 CAR T-cells for children and young adults with relapsed/refractory CD22+ hematologic malignancies. Additional analyses included correlation of hematologic toxicities with neurotoxicity and

SUBMITTER: Jess J 

PROVIDER: S-EPMC10277551 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature