Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma

ABSTRACT: Highlights • CAF subsets in HNSCC are significantly heterogeneous.• CKS2+ iCAFs are significantly associated with poor prognosis and low immune cell infiltration.• CKS2+ iCAFs are localized in proximity to cancer cells and displays significant intercellular communication.• CKS2+ iCAFs show high metabolic activity and low immunotherapeutic response. Cancer-associated fibroblasts (CAFs) consist of heterogeneous cellular populations that contribute critical roles in head and neck squamous cell carcinoma (HNSCC). A series of computer-aided analyses were performed to determine various aspects of CAFs in HNSCC, including their cellular heterogeneity, prognostic value, relationship with immune suppression and immunotherapeutic response, intercellular communication, and metabolic activity. The pro

SUBMITTER: Mou T 

PROVIDER: S-EPMC10277597 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature