Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer.

ABSTRACT:

Background

Patient-derived xenograft (PDX) models involve the engraftment of tumour tissue in immunocompromised mice and represent an important pre-clinical oncology research method. A limitation of non-small cell lung cancer (NSCLC) PDX model derivation in NOD-scid IL2Rgamma^null (NSG) mice is that a subset of initial engraftments are of lymphocytic, rather than tumour origin.

Methods

The immunophenotype of lymphoproliferations arising in the lung TRACERx PDX pipeline were characterised. To present the histology data herein, we developed a Python-based tool for generating patient-level pathology overview figures from whole-slide image files; PATHOverview is available on GitHub (https://github.com/EpiCENTR-Lab/PATHOverview).

Results

Lymphoproliferatio

SUBMITTER: Pearce DR 

PROVIDER: S-EPMC10277614 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature