Resting-state functional connectivity indicators of risk and resilience for self-harm in adolescent bipolar disorder.

ABSTRACT:

Background

Suicide is the second leading cause of death in all youth and among adults with bipolar disorder (BD). The risk of suicide in BD is among the highest of all psychiatric conditions. Self-harm, including suicide attempts and non-suicidal self-injury, is a leading risk factor for suicide. Neuroimaging studies suggest reward circuits are implicated in both BD and self-harm; however, studies have yet to examine self-harm related resting-state functional connectivity (rsFC) phenotypes within adolescent BD.

Methods

Resting-state fMRI data were analyzed for 141 adolescents, ages 13-20 years, including 38 with BD and lifetime self-harm (BD_SH+), 33 with BD and no self-harm (BD_SH-), and 70 healthy controls (HC). The dorsolateral prefrontal cortex (dlPFC

SUBMITTER: Dimick MK 

PROVIDER: S-EPMC10277718 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature