Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunities.

ABSTRACT: Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety of physiological processes, including development of multiple diseases. In particular, alternative splicing is profoundly involved in cancer progression through abnormal expression or mutation of splicing factors. Small-molecule splicing modulators have recently attracted considerable attention as a novel class of cancer therapeutics, and several splicing modulators are currently being developed for the treatment of patients with various cancers and are in the clinical trial stage. Novel molecular mechanisms modulating alternative splicing have proven to be effective for treating cancer cells resistant to conventional anticancer drugs. Furthermore, molecular mechanism-based combination strategies a

SUBMITTER: Araki S 

PROVIDER: S-EPMC10277747 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature