Ameliorative patterns of grey matter in patients with first-episode and treatment-naive schizophrenia.

ABSTRACT:

Background

Grey matter (GM) reduction is a consistent observation in established late stages of schizophrenia, but patients in the untreated early stages of illness display an increase as well as a decrease in GM distribution relative to healthy controls (HC). The relative excess of GM may indicate putative compensatory responses, though to date its relevance is unclear.

Methods

343 first-episode treatment-naïve patients with schizophrenia (FES) and 342 HC were recruited. Multivariate source-based morphometry was performed to identify covarying 'networks' of grey matter concentration (GMC). Neurocognitive scores using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and symptom burden using the Positive and Negative Symptoms Scale (PANSS) were obtained. Bivar

SUBMITTER: Li M 

PROVIDER: S-EPMC10277763 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature