Ontology highlight
ABSTRACT:
SUBMITTER: Kojima H
PROVIDER: S-EPMC10277823 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Stem cell reports 20230601 6
Cardiac transcription factors (TFs) directly reprogram fibroblasts into induced cardiomyocytes (iCMs), where MEF2C acts as a pioneer factor with GATA4 and TBX5 (GT). However, the generation of functional and mature iCMs is inefficient, and the molecular mechanisms underlying this process remain largely unknown. Here, we found that the overexpression of transcriptionally activated MEF2C via fusion of the powerful MYOD transactivation domain combined with GT increased the generation of beating iCM ...[more]