Ontology highlight
ABSTRACT:
SUBMITTER: Kurland JV
PROVIDER: S-EPMC10277839 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Kurland Jesse V JV Cutler Alicia A AA Stanley Jacob T JT Betta Nicole Dalla ND Van Deusen Ashleigh A Pawlikowski Brad B Hall Monica M Antwine Tiffany T Russell Alan A Allen Mary Ann MA Dowell Robin R Olwin Bradley B
Stem cell reports 20230601 6
Skeletal muscle function and regenerative capacity decline during aging, yet factors driving these changes are incompletely understood. Muscle regeneration requires temporally coordinated transcriptional programs to drive myogenic stem cells to activate, proliferate, fuse to form myofibers, and to mature as myonuclei, restoring muscle function after injury. We assessed global changes in myogenic transcription programs distinguishing muscle regeneration in aged mice from young mice by comparing p ...[more]