Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations.

ABSTRACT: Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness, the latter is one responsible for potentiating the resistance to treatment, inter alia due to increased invasiveness. In recent years, glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements, whereas the impact of the cytoskeleton on invasiveness is well known. Although non-stem glioblastoma cells are less invasive than glioblastoma stem cells (GSCs), these cells also acquire stemness with greater ease if characterized as invasive cells and not tumor core cells. This suggests that glioblastoma stemness should be further investigated for any phenomena related to the cytoskeleton and metabolism, as they may provide new invasion-related insigh

SUBMITTER: Kaluzinska-Kolat Z 

PROVIDER: S-EPMC10277965 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature